With time, the brain adjusts to the excess dopamine, which minimizes the higher that the person feels in comparison to the higher they felt when very first taking the drug?�an effect referred to as tolerance. They might take extra of your drug, striving to realize exactly the same dopamine superior.
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A bolus could be the administration of a medication, drug or other compound that's given to boost its concentration in blood rapdily to an effective stage, regardless of the route of administration